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Host-derived proteomic biomarkers for discriminating the tuberculosis disease spectrum in a Brazilian cohort

delete2026-06-26
delete0
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OA
AI
M
Matheus R. Almeida
A
Anouk van Hooij
L
Louise Pierneef
G
Gaby Wassenaar
R
Raquel da Silva Corrêa
R
Roberto Stefan de Almeida Ribeiro
L
Luana Karen Correia dos Santos
A
Ariane Leite de Oliveira
A
Ana Paula Santos
T
Thiago Thomaz Mafort
R
Rogério Rufino
C
Cristiana Santos de Macedo
P
Paul L.A.M. Corstjens
L
Luciana Silva Rodrigues
A
Annemieke Geluk *
DOI：10.1016/j.tube.2026.102794delete
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Abstract

Abstract

En 中文
• UCP-LFAs quantify host proteins in serum and pleural fluid in a Brazilian TB cohort. • Combined host protein quantification improves discrimination of P(L)TB from LTBI. • Serum CRP, ferritin, IL-6, and SAA1/A2 allow treatment monitoring in pleural TB.
Keywords:
Tuberculosis
LTBI
Pleural tuberculosis
Host proteomic biomarker
Triage test
Upconverting reporter particle
Lateral flow assay
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Tuberculosis cover
Tuberculosis
IF:
2.9
Papers:
147
Citations:
3.6K

Organization

U
uerj
Scholars:
27
Papers: 13
Citations: 1
R
rio de janeiro state university
Scholars:
146
Papers: 69
Citations: 0
L
leiden university medical center
Scholars:
1.2K
Papers: 396
Citations: 0
F
fiocruz
Scholars:
422
Papers: 135
Citations: 0
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