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Host transcriptional corepressor TLE1 is commonly exploited by RNA viruses for replication
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DOI：10.1016/j.molcel.2026.06.043.png)
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Abstract
En 中文
• IAV NS1 and SARS-CoV-2 NSP1 transactivate host TLE1 gene expression • IAV NP and SARS-CoV-2 N proteins bind TLE1 via a conserved bHLH-like motif • Viral NP/N binds TLE1 to promote polymerase activity and dampen the interferon response • TLE1 recruits host KLF4 to antagonize the cellular antiviral response
Keywords:
transcriptional corepressor
TLE1
viruses
antiviral peptide
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