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HSF1 in aging: The output selection model
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DOI：10.1016/j.mad.2026.112225.png)
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Abstract
En 中文
• A comprehensive review on HSF1 structure, function and regulation. • Inducible, maintenance, and growth-supporting HSF1 outputs are separable. • Life history-coupled allocation of HSF1 outputs explains age-related alterations. • Protective HSF1 outputs can be restored without reinforcing cancer risk.
Keywords:
Aging
HSF1
Proteostasis
Stress responses
Heat-shock
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