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HSF1-UCHL1 transcriptional axis protects against MASLD via regulation of PPARα protein stability
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DOI：10.1016/j.metabol.2026.156733.png)
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Abstract
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• Hepatic HSF1 levels are regulated by ATF3 and decreased during MASLD. • HSF1-LKO mice aggravates, while HSF1-LOE protects mice from MASLD via Pparα. • Hsf1 activation regulates Uchl1 transcription to enhance Pparα protein stability. • Uchl1-LOE and fenofibrate rescued Hsf1 deficiency caused hepatic lipid dysfunction.
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