Huang-Lian-Jie-Du Decoction alleviates cognitive deficits in Alzheimer’s disease via aromatase-mediated regulation of Aβ metabolism

Mingguang Sun

doi:10.1016/j.phymed.2026.158467

Huang-Lian-Jie-Du Decoction alleviates cognitive deficits in Alzheimer’s disease via aromatase-mediated regulation of Aβ metabolism

2026-06-18

0

PRE

AI

M

Mingguang Sun

D

Dongsheng Ye

P

Puxuan Min

M

Mengxiong Guo

X

Xiao Zhao

Y

Yue Zhou

L

Lingxu Xu

Y

Yi Wu

Z

Zhaoyou Meng *

G

Gesheng Wang *

DOI：10.1016/j.phymed.2026.158467

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Abstract

En 中文

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and pathological accumulation of amyloid-β (Aβ). Hippocampal aromatase (AROM), a key enzyme for local estrogen biosynthesis, has emerged as an important regulator of Aβ metabolism. Huang-Lian-Jie-Du Decoction (HLJD), a classical traditional Chinese medicine formula, has shown therapeutic potential in AD; however, its molecular mechanism remains largely unclear.

Keywords:

HLJD

Alzheimer’s disease

Aromatase

Aβ homeostasis

Estrogen

Huang-Lian-Jie-Du Decoction alleviates cognitive deficits in Alzheimer’s disease via aromatase-mediated regulation of Aβ metabolism

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