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Human iPSC-derived engineered heart tissue model of diastolic dysfunction in heart failure with preserved ejection fraction
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DOI：10.1016/j.stem.2026.06.007.png)
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Abstract
En 中文
• hiPSC-derived engineered heart tissues recapitulate key features of HFpEF • SGLT2i ameliorates the HFpEF-like phenotype via anti-inflammatory effects • Restoration of endothelial eNOS-NO-cGMP-PKG signaling mediates SGLT2i effects
Keywords:
heart failure with preserved ejection fraction
HFpEF
human induced pluripotent stem cells
engineered heart tissue
sodium-glucose cotransporter 2 inhibitor
SGLT2i
drug discovery
diastolic dysfunction
eNOS-NO-cGMP-PKG signaling pathway
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