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Human neuron subtype programming via single-cell transcriptome-coupled patterning screens
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DOI：10.1126/science.adn6121.png)
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Abstract
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The use of human induced pluripotent stem cells to generate induced neurons is used in a broad range of neuroscience studies, from disease modeling to drug screening. However, replicating the large heterogeneity of human neurons is challenging. Lin et al. performed a systematic screening of 480 morphogen combinations coupled with overexpression of one of two different transcription factors to generate a library of induced neurons successively analyzed using single-cell RNA sequencing. The authors identified a broad range of neuronal subtypes and mapped them along the anterior-posterior and dorsal-ventral axes of neural tube development. The results provide a valuable resource for engineering human neurons. —Mattia Maroso
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