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Human Olfaction without Apparent Olfactory Bulbs
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DOI：10.1016/j.neuron.2019.10.006.png)
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Abstract
En 中文
The olfactory bulbs (OBs) are the first site of odor representation in the mammalian brain, and their unique ultrastructure is considered a necessary substrate for spatiotemporal coding of smell. Given this, we were struck by the serendipitous observation at MRI of two otherwise healthy young left-handed women, yet with no apparent OBs. Standardized tests revealed normal odor awareness, detection, discrimination, identification, and representation. Functional MRI of these women's brains revealed that odorant-induced activity in piriform cortex, the primary OB target, was similar in its extent to that of intact controls. Finally, review of a public brain-MRI database with 1,113 participants (606 women) also tested for olfactory performance, uncovered olfaction without anatomically defined OBs in similar to 0.6% of women and similar to 4.25% of left-handed women. Thus, humans can perform the basic facets of olfaction without canonical OBs, implying extreme plasticity in the functional neuroanatomy of this sensory system.
Keywords:
SMELL IDENTIFICATION TEST
NEUROPSYCHOLOGY
DISCRIMINATION
NEURONS
QUALITY
VOLUME
LOGIC
TESTS
RAT
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