Human-specific gene expansions contribute to brain evolution

doi:10.1016/j.cell.2025.06.037

Human-specific gene expansions contribute to brain evolution

2025-07-21

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PRE

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D

Daniela C. Soto

J

José M. Uribe‐Salazar

Natasha Ann F. Mariano

DOI：10.1016/j.cell.2025.06.037

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Abstract

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• Identified 1,002 human-duplicated paralogs in the T2T-CHM13 genome • 148 gene families represent possible drivers of human brain evolution • Some paralogs exhibit remarkable selection signatures, including T cell marker CD8B • Zebrafish models show human-specific GPR89B and FRMPD2B impact brain phenotypes

Keywords:

human-duplicated paralogs

brain evolution

selection signatures

zebrafish models

gene families

Human-specific gene expansions contribute to brain evolution

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