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Human systemic and mucosal immune responses support further exploration of a Klebsiella pneumoniae protein-based vaccine
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DOI：10.1016/j.vaccine.2026.128893.png)
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Abstract
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Neonatal sepsis caused by Klebsiella pneumoniae is a major cause of under-five mortality in sub-Saharan Africa, and the rapid increase of infections caused by bacteria resistant to most or all available antimicrobials severely limits treatment options. An effective, maternally-administered vaccine could make a substantial reduction in neonatal sepsis and associated negative outcomes, as well as reduce the overall need for antimicrobials, a key driver of antimicrobial resistance. This exploratory, hypothesis-generating pilot study investigated the potential for a maternally administered protein-based vaccine to provide neonatal protection via antibodies transferred transplacentally and through breastfeeding.
Keywords:
Maternal vaccine
Sub-Saharan Africa
Neonatal sepsis
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