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Humanizing acidic mammalian chitinase variants establish lung immune conditioning and control environmentally driven inflammation and fibrosis
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DOI：10.1016/j.celrep.2026.117833.png)
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Abstract
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• Humanized (hChia) mice recapitulate common human AMCase activity variants in vivo • Basal lung inflammatory tone is elevated in low-activity hChia mice • Allergic, viral, and fibrotic lung disease is exacerbated in low-activity hChia mice • Chitinase reduces inflammatory effects of chitin from patients with acute lung injury
Keywords:
chitin
chitinase
AMCase
CHIA
gene-environment interaction
lung inflammation
pulmonary fibrosis
alveolar macrophages
IL-1β signaling
immune conditioning
CP: immunology
CP: genomics
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