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Humanizing pig kidneys via chimeric complementation
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DOI：10.1038/s41422-023-00881-5.png)
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Abstract
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An ultimate goal in stem cell research is to use induced pluripotent stem cells (iPSCs) to generate transplant able human organs in large livestock. In a groundbreaking study by Wang et al., the researchers showcased that by combining an optimized iPSC culture, tactics to boost the survival and competitive edge of donor human cells, and a genetically vacated host organ niche, they could successfully produce a humanized mesonephros within pig fetuses, a significant leap in the field
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Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis.png)
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