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HuR coordinates systemic aging through platelet infiltration
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DOI：10.1038/s41467-026-72481-x.png)
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Abstract
En 中文
Aging involves morphological and functional changes across different organs, but how these changes are linked among the different organs remains to be elucidated. Here, we uncover a central role of platelets in systemic aging. In aged mice, the levels of platelet-secreted pro-inflammatory factors (PSPF) increased greatly in the serum and platelets, leading to a diffuse increase of platelet infiltration in the brain, liver, lung, kidney, and aortic root. The RNA-binding protein HuR/ELAVL1, a major regulator of RNA metabolism, promoted the production of PSPF in platelets. Platelet-specific deletion of HuR reduced the expression of PSPF in platelets, alleviated platelet infiltration in the brain, liver, lung, kidney, and aortic root, and delayed systemic aging. By using single-nucleus sequencing, platelet-specific HuR ablation was found to alleviate p53 and pro-inflammatory signaling pathways in liver, lung, and brain tissues in aged mice. Our findings highlight a role of platelets in coordinating aging traits across organs. This research reveals that platelet infiltration initiated by the platelet HuR-PSPF regulatory process coordinates systemic aging. Targeting platelet HuR may be a promising strategy for anti-aging interventions
Keywords:
platelets
systemic aging
HuR
platelet infiltration
pro-inflammatory factors
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