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Hybrid cellular automaton-based model for quorum sensing-controlled biofilm evolution
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DOI：10.1016/j.compbiomed.2026.111852.png)
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Abstract
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• Novel hybrid cellular automaton model integrating quorum sensing as localized feedback mechanism. • AHL concentration modulates spreading probability via threshold-dependent activation. • Discrete analogues of reaction-diffusion equations for nutrients and signals. • 2D simulations reveal emergent biofilm morphologies from local interactions. • Quorum sensing-controlled spreading relates population density to spatial expansion dynamics.
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