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HYDRA-EDGE: HYDrogel-based rapid assay with entropy-driven gel enhancement for point-of-care viral detection
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PRE
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A
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J
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T
杨
D
J
M
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DOI：10.1016/j.cej.2026.180447.png)
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Abstract
En 中文
• HYDRA-EDGE is a portable POCT biosensor fusing DNA hydrogels, microfluidics, and glucose sensing. • The engineered bi-legged DNA walker drives enzyme-free cascade amplification, delivering ultrahigh sensitivity beyond single-leg systems and commercial kits. • The DNA hydrogel matrix ensures spatial confinement, stable enzyme encapsulation, and ambient stability for field use. • Clinically validated against RT-PCR, it accurately detects influenza A/B and SARS-CoV-2 with simple handling and low cost, enabling robust on-site multiplex diagnostics.
Keywords:
Entropy-driven
DNA hydrogel
Point-of-care testing
Glucose biosensing
Respiratory virus
Journal
IF:
13.2
Papers:
7.2W
Citations:
48.5W
Organization
Cited Papers