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Hypoxia and ascorbic acid: two interconnected microenvironmental factors driving collagen biosynthesis
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DOI：10.1016/j.matbio.2026.102007.png)
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Abstract
En 中文
• Ascorbic acid and low oxygen levels (hypoxia) promote collagen biosynthesis • Both factors act on collagen hydroxylases but through different mechanisms • Reciprocal regulation complicates the prediction of the net effect on fibrogenesis • Hypoxia-inducible factors control ascorbic acid intracellular uptake via GLUT1 • Unravelling this complex interplay will help anti-fibrotic therapy design
Keywords:
ascorbic acid
hypoxia
collagen biosynthesis
hypoxia-inducible factors
fibrogenesis
