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Hypoxia-preconditioned mitochondrial transplantation multidirectionally modulates Schwann cell functions to repair peripheral nerve injury in rats

delete2026-07-13
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OA
AI
J
J I A N Z E Dong
B
Bing Yan
X
Xushen Zhao
J
Jinyu Bai
H
Huajian Shan
X
Xiang Gao
L
Lei Sheng
J
Jun Dai
F
Fengxian Jiang
M
Mingchao Zhang
C
Chaowen Bai *
X
Xiaozhong Zhou *
S
Shuai Wei *
DOI:10.1016/j.jot.2026.101171delete
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Abstract

Abstract

En 中文
Peripheral nerve injury (PNI) often leads to sensory and motor dysfunction. This study investigated the promoting effect of hypoxia-preconditioned mitochondrial transplantation on the structural and functional reconstruction of peripheral nerves and the molecular mechanisms involved.
Keywords:
Dedifferentiation
Hypoxia
Mitochondrial transplantation
Nerve regeneration
Peripheral nerve injury
Schwann cell
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Journal

Journal of Orthopaedic Translation cover
Journal of Orthopaedic Translation
IF:
7.8
Papers:
1.1K
Citations:
4.1K

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