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Icariin alleviates ovariectomy-induced osteoporosis by promoting M2 macrophage polarization and suppressing osteoclast activation

delete2026-07-03
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PRE
AI
Y
Yongdong Yang *
C
Chuan Luo
X
Xingyu Ren
Q
Qiusheng Tan
C
Caifu Deng
DOI：10.1016/j.cyto.2026.157186delete
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Abstract

Abstract

En 中文
• Icariin preserves BMD and trabecular architecture in OVX mice. • Micro-CT shows icariin improves BV/TV and trabecular number. • Icariin reduces CTSK-positive osteoclast activity in femoral bone. • Icariin shifts macrophages toward an M2-like anti-inflammatory phenotype. • Icariin suppresses inflammatory cytokines and osteoclast activation markers.

Journal

Cytokine cover
Cytokine
IF:
3.7
Papers:
9.7K
Citations:
1.4W

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