Identification of rs2036527 as a cis-regulatory variant for CHRNA3 and CHRNA5 by allele-specific expression and implications for nicotine dependence and lung cancer

Tao Peng

doi:10.1111/ajad.70074

Identification of rs2036527 as a cis-regulatory variant for CHRNA3 and CHRNA5 by allele-specific expression and implications for nicotine dependence and lung cancer

2025-08-03

0

PRE

AI

T

Tao Peng

X

Xiaoqian Shi

H

Hao Guo

李

李海艳 (Haiyan Li)

X

Xi-Ting Zhou BS

H

Hongli Song

张欣欣 (Xinxin Zhang)

W

Wei‐Ping Fu *

C

Chang Sun *

DOI：10.1111/ajad.70074

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Numerous genome-wide association studies suggest that rs1051730 is significantly associated with nicotine dependence and further lung cancer in Caucasian. Since rs1051730 is a synonymous variant at CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit), it might be hypothesized that the causal variant might be other SNP(s) in strong linkage disequilibrium (LD).

Identification of rs2036527 as a cis-regulatory variant for CHRNA3 and CHRNA5 by allele-specific expression and implications for nicotine dependence and lung cancer

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