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Identifying the Influential Dynamic Inputs in Cost-Effectiveness Analyses
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DOI：10.1016/j.jval.2025.03.016.png)
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Abstract
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• Arguments for incorporating a drug’s pricing dynamics into cost-effectiveness analysis have become even more compelling since the passage of the Inflation Reduction Act, and this study suggests which dynamic inputs have the greatest influence on a cost-effectiveness estimate. • The incorporation of drug dynamics, especially post-loss-of-exclusivity drug prices, can substantially influence cost-effectiveness estimates, with potentially larger impacts on the cost-effectiveness of chronically administered treatments than for 1-time administration treatments. • By omitting drug dynamics, conventional, static cost-effectiveness estimates may be a misrepresentation of costs and therefore opportunity costs.
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