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IDH-genotype-linked kinase rewiring accompanies enhanced therapeutic response to dual-drug ferritin nanocages in high-grade glioma

delete2026-08-06
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OA
AI
M
Mara Schietinger
S
Sabri E. M. Sahnoun
E
Edda J. Krug
P
Philipp N. Loewe
P
Paolo Alimonti
E
Emiel P. C. van der Vorst
N
Najaf Mammadbayli
A
Agnieszka Morgenroth
D
Daniel Müller
E
Eva Miriam Buhl
A
Alaa A. Gad
B
Bernd Neumaier
F
Felix M. Mottaghy
J
Jörg B. Schulz
K
Katherine A. Vallis
P
Pardes Habib *
DOI：10.1016/j.mtbio.2026.103539delete
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Abstract

Abstract

En 中文
• Biodegradable FTH1 nanocages enable dual-drug glioma therapy. • 68 Ga-labeled FTH1 nanocages integrate PET imaging and therapy. • Dual-drug nanotherapy suppresses glioma growth in ovo. • Kinomics profiling reveals IDH-dependent kinase signaling adaptation.
Keywords:
Protein nanocarrier
Blood-brain barrier
Glioblastoma
Chemotherapeutic payload
PET
Imaging
Kinase signaling

Journal

Materials Today Bio cover
Materials Today Bio
IF:
10.2
Papers:
3.6K
Citations:
9.5K

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C
computer and natural sciences
Scholars:
2
Papers: 1
Citations: 0
U
University of Cologne
Scholars:
2.9W
Papers: 2.1W
Citations: 2.4W
U
university of oxford
Scholars:
9.6W
Papers: 8.5W
Citations: 137
R
rwth aachen university
Scholars:
3.0K
Papers: 1.0K
Citations: 0
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