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IgA-Enriched Phenotype Predicts Liver-Related Events in MASLD
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DOI：10.1016/j.jhep.2026.06.044.png)
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Abstract
En 中文
• IgA-based clustering revealed a high-risk MASLD subgroup with increased liver-related events. • Elevated serum IgA independently predicted liver-related events beyond fibrosis stage. • Multiple lines of evidence suggested enhanced IgA-associated immune responses in both the gut and liver. • IgA-expressing B-lineage cells were enriched in portal regions of MASLD livers. • Spatial transcriptomics revealed IGHA1 co-expression with immune- and extracellular matrix–related genes.
Keywords:
fibrosis
IGHA1
machine learning
spatial transcriptomics
gut-liver axis
intestinal permeability
Journal
IF:
33
Papers:
3.2W
Citations:
6.5W
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Cited Papers