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IL-6 boosts synaptogenesis STAT!
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DOI：10.1016/j.immuni.2021.10.010.png)
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Abstract
En 中文
Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity, Mirabella et al. (2021) show that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.
Keywords:
FETAL-BRAIN DEVELOPMENT
SCHIZOPHRENIA
INTERLEUKIN-6
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