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Immunophenotype and proviral landscape of HTLV-1c infection and pulmonary disease

delete2026-07-23
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OA
AI
A
Ashley Hirons
N
Natasha Jansz
G
Georges Khoury
P
Paula Ellenberg
S
Sarah Collins
J
James Cooney
J
John Zaunders
L
Lewis Williams
K
Kirthi Nandha Nair
A
Ashley Huey Yiing Yap
N
Nicholas Hirons
L
Liana Mackiewicz
M
Merle Dayton
L
Le Wang
D
Daniel Sijmons
M
Mohammad Radwanur Talukder
A
Allegra Holloway Vickas
A
Amy W. Chung
M
Marcel Doerflinger
M
Marc Pellegrini
DOI：10.1016/j.ebiom.2026.106403delete
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Abstract

Abstract

En 中文
Human T-lymphotropic virus 1 (HTLV-1) integrates into host DNA, resulting in life-long infection that underlies malignancy, inflammatory disease, and early all-cause mortality. HTLV-1 subtype-C endures as an endemic infection in Central Australia, and is associated with pulmonary disease. The cellular and viral features driving HTLV-1c pathogenesis remain poorly understood.
Keywords:
HTLV-1
Defective and chimeric provirus
Bronchiectasis
Lung-homing CD4+ T-cells
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EBioMedicine cover
EBioMedicine
IF:
10.8
Papers:
6.4K
Citations:
3.2W

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