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Immunophenotypic assessment of pure embryonal carcinoma and yolk sac tumour suggests that reprogramming to non-seminoma occurs outside the spermatogonial niche
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DOI：10.1111/his.70160.png)
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Abstract
En 中文
Germ cell neoplasia in situ (GCNIS) is the precursor of GCNIS-derived testicular germ cell tumours, including seminomas and non-seminomas. Most non-seminomas show mixed histology, often including components of seminoma. A small subset presents as pure non-seminomatous germ cell tumors. In these neoplasms, the absence of invasive seminoma. raises the possibility that reprogramming to non-seminoma may occur at an early in-situ stage (i.e., within the spermatogonial niche). This study examined GCNIS associated with pure embryonal carcinoma (EC) and postpubertal-type yolk sac tumour (YST) using immunohistochemistry for transcription factors characteristic of GCNIS/seminoma, EC, and YST phenotypes to determine if reprogramming to non-seminoma occurs within the spermatogonial niche.
Keywords:
embryonal carcinoma
germ cell neoplasia in situ
immunohistochemistry
yolk sac tumour
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