.png){kind=icon}
.png){kind=icon}
Return
Impact of High-Intensity Statins and Low-Density Lipoprotein Cholesterol on the Outcomes of Coronary Intervention for Chronic Coronary Syndrome in Japan
.png){kind=icon}
PRE
AI
Y
K
D
K
S
H
K
K
T
M
M
H
DOI：10.5551/jat.66062.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Aim: The clinical effect of high-intensity statin therapy after percutaneous coronary intervention (PCI) in Japanese patients with chronic coronary syndrome (CCS) remains unclear. We investigated the association between high-intensity statin therapy and the cardiovascular outcomes following PCI in patients with CCS. Methods: We retrospectively evaluated 716 patients with CCS who underwent PCI and categorized them into high- or non-high-intensity statin groups, according to the Japan Atherosclerosis Society guidelines. The primary outcome was a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and revascularization, while the secondary outcome was all-cause death. The outcomes were further assessed according to the low-density lipoprotein cholesterol (LDL-C) levels (<55 mg/dL, 55-69 mg/dL, and >= 70 mg/ dL). The hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using the Cox model. Results: Over a median follow-up of 2 years, high-intensity statin therapy reduced the incidence of the primary outcome (HR, 0.32; 95% CI, 0.17-0.61; P<0.01) and all-cause death (HR, 0.18; 95% CI, 0.06-0.57; P<0.01). Thi s association with the primary composite outcome was consistently observed across the achieved LDL-C categories. Conclusions: High-intensity statin therapy was associated with a reduced risk of cardiovascular events after PCI in Japanese patients with CCS, independent of the achieved LDL-C levels.
Keywords:
High-intensity statins
Chronic coronary syndrome
Percutaneous coronary intervention
LDL cholesterol
Cardiovascular outcome
Journal
J
IF:
2.8
Papers:
2.4K
Citations:
4.7K
Organization
Cited Papers