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Impact of icosapent ethyl on serum lipoand glycoprotein profiles assessed by 1H-NMR. A real-world observational study (IPE-NMR)
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DOI：10.1016/j.numecd.2026.104852.png)
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Abstract
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• High triglycerides drive widespread lipoprotein metabolic derangement. • 1H-NMR reveals lipoprotein changes missed by standard lipid testing. • High TG is linked to TRL remnants, remnant cholesterol, smaller LDL and triglyceride enriched HDL. • Serum NMR detects subclinical systemic inflammation in high-TG patients. • IPE improves lipoprotein and inflammatory profiles beyond TG lowering.
Keywords:
Icosapent ethyl
Reduce-it trial
High triglycerides
NMR lipoprotein profile
Lipoprotein particle number
Glycoproteins
Cardiovascular prevention
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