.png){kind=icon}
.png){kind=icon}
Return
Impact of immunosuppression on the incidence of ventilator-associated events: an observational study
.png){kind=icon}
PRE
AI
V
K
M
P
S
DOI：10.1186/s12871-026-03804-0.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Background Critically ill immunocompromised patients requiring mechanical ventilation (MV) may be particularly vulnerable to ventilator-associated events (VAE), yet the impact of baseline immunosuppression on VAE incidence remains unclear. Methods We conducted a secondary analysis of a cohort of adults requiring MV for >= 4 days in two ICUs of a tertiary hospital in Moscow, Russia. Using competing-risk regression, we compared the 30-day incidence of VAE between immunocompromised and non-immunocompromised patients. We then evaluated the association between VAE and 30-day ICU mortality among immunocompromised patients using Cox regression. Results Of 269 patients, 122 (45.4%) had baseline immunosuppression. The incidence of any VAE was higher in immunocompromised patients, though the estimate was imprecise (adjusted subhazard ratio [aSHR] 1.64; 95% CI 0.82-3.30); for infection-related ventilator-associated complications (IVAC), the estimate suggested a more than twofold increased hazard, but with considerable uncertainty (aSHR 2.22; 95% CI 0.85-5.78). In patients with immunosuppression, IVAC were associated with increased mortality (adjusted hazard ratio 2.38; 95% CI 1.16-4.89). Conclusion Despite a higher estimated incidence of VAE in immunocompromised patients, we could not establish a clear association between baseline immunosuppression and VAE risk. IVAC were associated with increased mortality in immunocompromised patients, although this finding should be considered exploratory.
Keywords:
Ventilator-associated events
Immunosuppression
Mechanical ventilation
Journal
IF:
2.6
Papers:
464
Citations:
6.3K