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Impact of Lactobacillus gasseri LG08 on weight management and endocrine function in overweight women: A randomized clinical trial
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DOI：10.1016/j.jff.2026.107389.png)
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Abstract
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• L. gasseri LG08 significantly reduced body weight, BMI, and waist-hip ratio in overweight women (all p < 0.05). • LG08 improved metabolic hormones: decreased leptin and increased GLP-1 and PYY (all p < 0.001). • LG08 reduced estradiol and prolactin (p < 0.01), enriched Bifidobacterium, Parabacteroides, and maintained α-diversity. • No adverse effects were reported, supporting LG08 as a safe probiotic intervention for metabolic health.
Keywords:
Lactobacillus gasseri
Overweight
Body mass index
Glucagon-like peptide-1
Gut microbiota
Randomized controlled trial
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