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Impact of nanoplastics on human induced pluripotent stem cell-derived endothelial cells and blood vessel organoids

delete2026-03-02
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OA
AI
R
Rui Zhang
X
Xue Wang
X
Xinyu Fu
L
Liliang Ouyang
周
周博达 (Boda Zhou) *
J
Jie Na *
DOI：10.1016/j.gce.2026.02.005delete
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Abstract

Abstract

En 中文
• 3D bioprinted BVOs evaluate size-dependent NPs vasculotoxicity. • 100 nm NPs reduce endothelial nodes to 373.7 with 90% junction loss. • NPs exposure impairs 3D vascular network assembly and cell viability. • ScRNA-seq reveals complete depletion of angiogenic endothelial populations. • EndMT-like shifts and signaling dysregulation are identified via scRNA-seq.
Keywords:
Nanoplastics
Blood vessel organoid
Human pluripotent stem cells
Endothelial cells
3D bioprinting

Journal

Green Chemical Engineering cover
Green Chemical Engineering
IF:
7.6
Papers:
350
Citations:
1.5K

Organization

T
Tsinghua University
Scholars:
8.6K
Papers: 4.1K
Citations: 17.7W
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