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Impacts of HLA-DR3DQ2 and HLA-DR4DQ8 haplotypes singly and combined on autoimmunity, phenotype and comorbidity in patients with Latent Autoimmune Diabetes in the adult. Results from the HUNT and ESTRID studies
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DOI：10.1016/j.jaut.2026.103576.png)
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Abstract
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• HLA haplotypes DR3DQ2 and DR4DQ8 are poorly characterized in LADA. • Data from two epidemiological cohorts provides a sound basis for analysis. • DR3DQ2 or DR4DQ8 in LADA patients associate with a severely diabetic phenotype. • This finding can explain, at least in part, the known heterogeneity of LADA. • DR4DQ8 may exert a stronger phenotypic impact than DR3DQ2.
Keywords:
HLA-DR3DQ2
HLA-DR4DQ8
LADA
autoimmune phenotype
comorbidity
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