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Implemented one-pot two step fully automated synthesis of [18F]FPIA for metabolic imaging applications
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DOI：10.1016/j.nucmedbio.2026.109605.png)
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Abstract
En 中文
[18F]Fluoropivalate ([18F]FPIA), also known as 18F-pivalate or 18F-RAD101, is the fluorinated analogue of pivalic acid and has shown promise in ongoing clinical trials for the detection of brain metastases. The original synthesis of [18F]FPIA involved a two-step procedure that was not fully automated, limiting its suitability for large-scale or GMP production. A subsequent report described an improved two-step, one-pot synthesis on a cassette-based module, although with certain limitations. Here, we present an optimized two-step, one-pot synthesis of [18F]FPIA using a vial-based automated synthesizer and demonstrate its successful implementation under GMP conditions. We also report [18F]FPIA-PET imaging in prostate cancer patient-derived xenograft (PDX) models.
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