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In silico quantification of the stiffness perceived by cells inside porous collagen-based scaffolds
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DOI：10.1016/j.matdes.2025.115412.png)
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Abstract
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• A simple metric of the stiffness perceived by cells inside microporous scaffolds. • Perceived stiffness in microporous scaffolds is defined by random cell attachment. • In some microporous scaffolds (collagen) cell force alters perceived stiffness. • Large deformations of struts dictate cell-level mechanics of porous scaffolds.
Keywords:
Cell-matrix interactions
Mechanosensing
Porous scaffolds
Biomaterial mechanics
Finite element method
In silico model
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