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In Situ Hybridization of Polymeric Curcumin to Arginine-Derived Carbon Quantum Dots for Synergistic Treatment of Bacterial Infections
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DOI：10.1021/acsami.3c04316.png)
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Abstract
En 中文
Effective infectious keratitis treatment must eliminatethe pathogen,reduce the inflammatory response, and prevent persistent damage tothe cornea. Infectious keratitis is generally treated with broad-spectrumantibiotics; however, they have the risk of causing corneal epithelialcell damage and drug resistance. In this study, we prepared a nanocomposite(Arg-CQDs/pCur) from arginine (Arg)-derived carbon quantum dots (Arg-CQDs)and polymeric curcumin (pCur). Partial carbonization of arginine hydrochloridein the solid state by mild pyrolysis resulted in the formation ofCQDs, which exhibited enhanced antibacterial activity. pCur was formedby the polymerization of curcumin, and further crosslinking reducedits cytotoxicity and improved antioxidative, anti-inflammatory, andpro-proliferative activities. The pCur in situ conjugated with Arg-CQDsto form the Arg-CQDs/pCur nanocomposite, which showed a minimum inhibitoryconcentration of ca. 10 mu g mL(-1), which was>100-fold and >15-fold lower than that of the precursor arginineandcurcumin, respectively, against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The Arg-CQDs/pCur nanocompositewith combined antibacterial, antioxidative, anti-inflammatory, pro-proliferativeproperties, and long-term retention on cornea enabled synergistictreatment of bacterial keratitis. In a rat model, it can effectivelytreat P. aeruginosa-induced bacterialkeratitis at a concentration 4000-fold lower than the commerciallyused drug, Sulmezole eye drops. Arg-CQDs/pCur nanocomposites havegreat potential for application in antibacterial and anti-inflammatorynanoformulations for clinical use to treat infectious diseases.
Keywords:
carbonization
polymerization
phytochemicals
multifunctional nanocomposites
bacterial infections
synergistic therapy
Journal
IF:
8.2
Papers:
6.1W
Citations:
38.7W
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