Transhorizontal Fissure Approaches to the Middle Cerebellar Peduncle: Quantitative Anatomical Analyses of the Retrosigmoid, Extended Retrosigmoid, and Presigmoid-Retrolabyrinthine Approaches

Irakliy Abramov

doi:10.1016/j.wneu.2025.124379

In vitro evaluation of anti-HIV radioimmunoconjugates labeled with astatine-211, thorium-227 and actinium-225

2026-01-23

0

PRE

AI

A

Anne-Sophie Kuhlmann *

D

Donald K. Hamlin

Y

Yawen Li

X

Xinyi Wang

L

Lily Li

C

Chris Orvig

H

Hans‐Peter Kiem

B

BM Sandmaier

D

D. Scott Wilbur

S

Seth H. Pincus

R

Robert D. Harrington *

DOI：10.1016/j.nucmedbio.2026.109602

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Abstract

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We conducted an in vitro investigation of the selective cytotoxicity of alpha-emitting radioimmunoconjugates (α-RICs) directed against cells expressing HIV envelope (Env) proteins. It is well known that monoclonal antibody (mAb)-targeted α-emitting radionuclides can effectively kill antigen-expressing cells; however, the expected low-level expression of HIV antigens on latently infected cells poses an obstacle to all anti-HIV immune-based treatments, including α-RICs. This investigation tested the cytotoxicity of the HIV envelope antigen-binding mAbs, PGT126 (binding gp120) and 7B2 (binding gp41), conjugated with labeling chelators that bind the α-emitters astatine-211 (211At), actinium-225 (225Ac) or thorium-227 (227Th).

In vitro evaluation of anti-HIV radioimmunoconjugates labeled with astatine-211, thorium-227 and actinium-225

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