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In vitro exposure to non-antipseudomonal antibiotics (NAPA) induces Pseudomonas aeruginosa resistance to antipseudomonal antibiotics (APA)
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DOI：10.1093/jac/dkag182.png)
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Abstract
En 中文
Pseudomonas aeruginosa readily evolves antimicrobial resistance through regulatory plasticity and stress-adaptive pathways. Clinically, antibiotics lacking intrinsic antipseudomonal activity are often favoured with the assumption that they avoid selective pressure on P. aeruginosa. Whether subinhibitory exposure to such ‘non-antipseudomonal antibiotics’ (NAPA) can nevertheless select for canonical resistance pathways remains incompletely defined.
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