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In Vitro Models in Chronic Obstructive Pulmonary Disease (COPD): Implications for New Diagnostic Strategies and Therapeutic Approaches
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DOI：10.3390/biology15141104.png)
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Abstract
En 中文
Chronic obstructive pulmonary disease (COPD) represents a major global health burden, prompting substantial efforts to identify and promote novel therapeutic strategies. However, the physiological relevance of conventional two-dimensional cell culture systems often limits the effectiveness of high-throughput screening approaches. This review explores three-dimensional models that better reproduce key structural and functional features of this complex, multifactorial disease. Particular attention is given to their application in evaluating emerging therapeutic approaches, including probiotics and extracellular vesicle-associated microRNAs.
Keywords:
COPD
air-liquid interface (ALI)
lung organoids
lung-on-a-chip
precision-cut lung slices (PCLS)
lung ECM-derived hydrogels
extracellular vesicles
microRNAs
organ failure
personalized medicine
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3.5
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2.3W
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