1
Return

In vitro recapitulation of intramuscular mRNA vaccination with naive and recall antigens using a human lymphoid follicle chip platform

delete2026-06-20
delete0
delete
OA
AI
Y
Yunhao Zhai
M
Min Wen Ku
K
Ka Yang
A
Aditya Patil
P
Pranav Prabhala
L
Liqun He
Y
Yuncheng Man
M
Mizanur Rahman
K
Kavya Menon
S
Sven B. Spörri
S
Supriya Gharpure
A
Abdul Rahman Isaacs
S
Shay Ferdosi
A
Andrzej S. Pitek
G
Giulietta Maruggi
S
Sylvie Bertholet
J
Jessica Firestone
K
Kambiz Mousavi
E
Eric Miller
K
Kate Luisi
DOI：10.1016/j.isci.2026.116416delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
• Human organ chip model to study antibody response to intramuscular mRNA vaccination • De novo IgG response to a naive antigen, in conjunction with an increase in lymphoid follicles, and cytokines • Distinct mechanisms for non-amplifying mRNA vs. self-amplifying mRNA • Somatic hypermutation and neutralizing antibodies observed during a recall response
Keywords:
biological sciences

Journal

iScience cover
iScience
IF:
4.1
Papers:
4.6K
Citations:
4.1W

Organization

No organization information available
Cited Papers

Cited Papers

Citing Papers

Citing Papers