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In vivo engineering of immunosuppressive T cells to treat ocular autoimmune diseases

delete2026-04-28
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PRE
AI
D
Dongliang Wang
J
Jie Ling
J
Jiangbo Liang
J
Jingni Li
Q
Qiuling Hu
L
Langqi Yang
J
Jiayi Jin
X
Xin Bai
Y
Ying-Feng Zheng *
B
Bingying Lin *
X
Xianchai Lin *
DOI：10.1016/j.exer.2026.111041delete
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Abstract

Abstract

En 中文
• Targeted delivery of Foxp3 using T-IDLE platform effectively reprograms endogenous T cells into functional, immunosuppressive Treg-like cells. • T-IDLEFoxp3 treatment effectively suppresses pathogenic responses, mitigates tissue inflammation, and prevents detrimental tissue remodelling. • This in vivo cell engineering strategy restores immune homeostasis with high lineage specificity and systemic safety.
Keywords:
T-IDLE platform
Foxp3
Treg-like cells
immunosuppressive T cells
ocular autoimmune diseases

Journal

Experimental Eye Research cover
Experimental Eye Research
IF:
2.7
Papers:
7.6K
Citations:
1.6W

Organization

G
Guangdong Provincial Key Laboratory
Scholars:
103
Papers: 26
Citations: 0
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