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Increased KIR + CD8+ T cell frequency with impaired cytotoxic potential in systemic lupus erythematosus
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DOI：10.1016/j.cca.2025.120792.png)
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Abstract
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• This study aimed to investigate the role of KIR+CD8+ regulatory T cells in SLE. • SLE patients exhibit a notable reduction in lymphocyte counts and an increase in effector CD4+ T cells, plasmablast, and CD8 + CD28-T cells, with no change in Treg cells compared to healthy controls. • CD8 + T cells highly express KIRs in SLE, and there is a negative correlation between the levels of CD158e + CD8 + T cells and disease activity. • KIR+CD8 + T cells in SLE demonstrate impaired cytotoxic functions, with downregulation of cytotoxicity-related genes.
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