INCREASED LEF1 PROTEIN LEVELS AND ISOFORM SWITCHING DRIVE CELL PROLIFERATION IN CHRONIC LYMPHOCYTIC LEUKEMIA

doi:10.1182/blood.2025030129

INCREASED LEF1 PROTEIN LEVELS AND ISOFORM SWITCHING DRIVE CELL PROLIFERATION IN CHRONIC LYMPHOCYTIC LEUKEMIA

2025-09-24

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Stella Charalampopoulou

Víctor Jiménez-Martínez

L

Liska Caviedes-Cárdenas

José I. Martı́n-Subero *

DOI：10.1182/blood.2025030129

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- In aggressive CLLs, increased stability elevates LEF1 protein levels which promote selective binding to cell cycle-related genes. - Lymph node-derived stimuli upregulate LEF1 protein levels and induce a shift towards short isoforms that promote CLL proliferation.

INCREASED LEF1 PROTEIN LEVELS AND ISOFORM SWITCHING DRIVE CELL PROLIFERATION IN CHRONIC LYMPHOCYTIC LEUKEMIA

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