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Incretin-based therapies and craving: a clinical signal pointing to reward reprogramming
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DOI:10.1016/j.numecd.2026.104818.png)
Abstract
En 中文
• Incretin therapies may reduce craving beyond metabolic effects • Tirzepatide could be linked to cocaine craving loss and abstinence • The possible mechanism of action could be the modulation of mesolimbic reward pathways (GLP-1 axis) • The present finding may support emerging link between metabolism and addiction biology • Calls for trials of incretin drugs in substance use disorders
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