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Individual Single-Crystalline Irregular In2O3 Microcavity for Ultrasensitive Semiconductor-Based SERS Biosensor
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DOI：10.1002/adma.202515510.png)
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Abstract
En 中文
Surface-enhanced Raman spectroscopy (SERS) achieves ultrahigh sensitivity at the molecular level and enables water-interference-free detection. However, the development of single-particle semiconductor substrates that do not rely on gap-enhanced electromagnetic fields remains challenging. Herein, capitalizing on the dual merits of morphology-induced prolonged light accumulation and structure-improved interfacial charge transfer, we developed an ultrasensitive semiconductor-based individually SERS system based on a highly crystalline irregular hexagonal prism In2O3 (I-In2O3) microcavity. Finite-difference time-domain simulations and photoluminescence spectra confirmed the successful establishment of a whispering-gallery-mode microcavity on the I-In2O3 platform. This microcavity enables the long-term confinement and oscillation of resonant photons, thereby significantly enhancing light–matter interactions. Aberration-corrected electron microscopy demonstrated that although I-In2O3 single crystals were isostructural to regular hexagonal prisms, they exhibit contracted lattice parameters. Density functional theory calculations further revealed that atomic-scale compressive lattice strain induces electronic band restructuring, enhancing the interfacial interactions between individual particle substrates and adsorbed molecules at the atomic level. In addition, the I-In2O3 SERS system demonstrates quantitative and multiplexing capabilities for rapid antibiotic detection. This work presents new perspectives for constructing supersensitive semiconductor SERS sensors using a micron-scale single-particle platform.
Keywords:
In2O3 microcavity
antibiotic detection
lattice-strain
single-particle SERS
whispering-gallery mode
Journal
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Citations:
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