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Inert-living matter, when cells and beads play together
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DOI：10.1038/s42005-020-00506-y.png)
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Abstract
En 中文
While both active and granular matter have been extensively studied, here we investigate what happens when we mix the two of them, in a model system combining microparticles and cell assemblies. On a substrate covered with polystyrene or silica microparticles, we notice two regimes in the spreading of a cell aggregate: light particles are pushed by the cells and form a ring, which bonds to the substrate by adhesion forces that oppose spreading, while for heavy particles, the cell monolayer spreads above the particle bed. In both cases, cell activity is transmitted to inert beads, leading to the formation of cell-microparticle aggregates, which flicker and diffuse. We then study the formation and the spreading of hybrid aggregates of microparticles and living cells and observe phase separations and jamming transitions. Our study may have implications on processes such as cancer metastasis and development, and may guide cancer therapies based on inert particles. Interaction of active matter with geometrical and topological constraints is a topic of intense research in the recent few years due to its potential for design and control of active flow patterns. Here, the authors experimentally study the growth and expansion of cell aggregates interleaved by passive colloidal particles, showing that inert particles can reshape the collective pattern formation in cellular aggregates.
Keywords:
ADHESION
DIFFUSION
DYNAMICS
MODEL
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