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Infection of ratites with clade 2.3.4.4b HPAIV H5N1: potential implications for zoonotic risk
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DOI：10.1080/22221751.2026.2645853.png)
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Abstract
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We detected H5N1 high pathogenicity avian influenza in captive Greater Rhea (Rhea americana). Viral genetic analysis revealed the mammalian associated PB2-E627 K mutation, indicating selection of mammalian-relevant mutations in ratites. Pathologic investigation of available tissues demonstrated severe multifocal necrotizing inflammation, and a strong vasculotropism.
Keywords:
Avian Influenza
viral adaptation
zoonotic risk
ratites
H5N1
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