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Inhibiting SIRT2 attenuates sepsis-associated acute kidney injury via NEU1 acetylation-mediated CD44/PI3K/AKT pathway activation

delete2026-06-26
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PRE
AI
Y
Yaqiong Jiang
D
Dan Li
L
Li Chen
Z
Zhijun Huang
B
Bin Yi *
DOI：10.1016/j.lfs.2026.124554delete
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Abstract

Abstract

En 中文
• SIRT2 has significantly interactions with NEU1 and SIRT2 deacetylates NEU1 at lysine 395 (K395). • The increase in the acetylation level of NEU1 reduces its sialidase activity and enhances CD44 sialylation. • The protective effect of NEU1 acetylation is via the CD44/PI3K/AKT signaling pathway. • Nano-AGK2 exhibits superior anti-renal injury effect compared to AGK2.
Keywords:
SIRT2
Acute kidney injury
NEU1
Inflammation

Journal

Life Sciences cover
Life Sciences
IF:
5.1
Papers:
1.7W
Citations:
4.7W

Organization

C
central south university
Scholars:
1.7W
Papers: 5.0K
Citations: 3
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