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Inhibition of eukaryotic translation initiation factor 1 A (eIF1A) and 3B (eIF3B) diminishes the psoriatic phenotype in two mouse models and human 3D model samples
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DOI：10.1016/j.jdermsci.2026.03.008.png)
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Abstract
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• Psoriasis is a chronic systemic inflammatory disease with polygenic predisposition and high comorbidity burden. • Dysregulated mRNA translation, particularly during initiation, may contribute to pathogenesis. • eIF1A and eIF3B are central players in translation initiation and have been linked to inflammation and hyperproliferation. • eIF1A and eIF3B are functionally relevant for keratinocyte hyperproliferation and psoriatic inflammation. • siRNA targeting of these eIFs is efficacious and safe in preclinical models. • Findings support further development of topical or systemic siRNA therapies or pharmacological eIF inhibitors as novel treatments for psoriasis.
Keywords:
Psoriasis
eukaryotic translation initiation factors
new therapeutic targets
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