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Innate immune dysregulation in multiple myeloma: molecular basis and mechanistic interventions
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DOI：10.1016/j.intimp.2026.116996.png)
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Abstract
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• Innateimmune dysregulation drivers multiple myeloma progression by fostering immune tolerance, tumor survival, and resistance. • NK and iNKT cell exhaustion, with MDSC and TAM expansion, creates an immunosuppressive niche driving MM progression. • Targeting innate immunity through NK/iNKT cells, checkpoint, metabolic, and microbiota-based therapies may improve MM.
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