Insulin like growth factor and cytokine signalling predict future cognitive impairment in Parkinson's disease

Maximilian Powell

doi:10.1016/j.nbd.2026.107570

Insulin like growth factor and cytokine signalling predict future cognitive impairment in Parkinson's disease

2026-08-09

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Maximilian Powell

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Nicolas Dzamko *

DOI：10.1016/j.nbd.2026.107570

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Abstract

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• Future cognitive decline in people with Parkinson's can be accurately predicted. • Proteins involved in cytokine signalling are major contributors to prediction models. • Potential biomarkers and/or pathways for therapeutic intervention have been indentified.

Keywords:

Machine learning

Inflammation

Cognitive decline

Cytokines

Parkinson's disease

Insulin like growth factor and cytokine signalling predict future cognitive impairment in Parkinson's disease

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