Insulin resistance, not hepatic histological features, is the dominant correlate of insulin clearance in class 3 obesity

Aika Miya

doi:10.1016/j.diabres.2026.113481

Insulin resistance, not hepatic histological features, is the dominant correlate of insulin clearance in class 3 obesity

2026-08-02

0

PRE

AI

A

Aika Miya

A

Andrea Tura

A

Anita Shokouhmehr

I

Irene Esposito

A

Aslihan Yavas

F

Frank A. Granderath

M

Matthias Schlensak

M

Maximilian Huttasch

G

Georgia Xourafa

G

Geronimo Heilmann

S

Sabine Kahl

M

Michael Roden

P

Patrick Schrauwen *

DOI：10.1016/j.diabres.2026.113481

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Abstract

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• Liver histology does not predict systemic insulin clearance in class 3 obesity. • Insulin resistance was the strongest independent correlate of insulin clearance. • Findings span from no MASLD to advanced MASH with fibrosis.

Insulin resistance, not hepatic histological features, is the dominant correlate of insulin clearance in class 3 obesity

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